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EXPLORING LINK BETWEEN ERECTILE DYSFUNCTION & URINARY TRACT INFECTION

EXPLORING LINK BETWEEN ERECTILE DYSFUNCTION & URINARY TRACT INFECTION.ERECTILE DYSFUNCTION,inability to maintain stable erection for sexual intercourse, is known to have high prevalence worldwide. It was estimated that there were over 152 million men suffering from erectile dysfunction worldwide. It is also predicted that there will be an increase of nearly 170 million men with erectile dysfunction till 2025, thus, the prevalence rate will hike to approximately 322 million men. According to Aytac IA et al., this prevalence rate has been observed to be high in Africa, Asia and South America.

As we look at URINARY TRACT INFECTION (UTI), then, it is one of its outcomes of erectile dysfunction. UTI is an infection that occurs within the urinary tract system, which consists of the urethra, bladder, ureter, and kidneys, as well as the prostate and testicles. It has been observed by Schaeffer A J et al. that the urinary tract infection is uncommon in men younger than 60 years of age (0.9 – 2.4% per 1000 men). The men older than 60 years of age have seen to be more prone to UTIs (7.7% per 1000 men).

Erectile dysfunction and urinary tract infection are correlated conditions. It is recommended that patients seeking consultation for one condition should always be screened for the other condition. Both erectile dysfunction and UTI affect sexual function and hence quality of life of men. In a large epidemiological study, 28.8% of men were reported to have a fall in sexual enjoyment and 24.8% had decreased or stopped sexual activity due to the disorders of prostate or bladder.

UTI is a strong enhancer of erectile dysfunction. Any patient with confirmed erectile dysfunction is always tested for urinary infection. Mild to moderate or moderate to severe UTIs, have a greater impact on erectile dysfunction.

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Infection of the prostate (prostatitis) can also lead to erectile problems. Prostatitis can be caused by a sexually transmitted disease or from the bacteria common in the feces (E. coli, etc.). Younger patients are more likely to get a sexually transmitted disease than a very old patient. Patients may get the infection from incomplete bladder emptying and the residual urine serves to propagate the bacteria. This condition can cause

  • Severe burning with urination
  • Painful ejaculation
  • Blood in the urine
  • Fever
  • Chills
  • Need to strain or push to get the urine out

None of these symptoms make sexual relationship a very attractive activity, which can ultimately lead to erectile dysfunction.

HOW CAN IT BE PREVENTED OR TREATED?

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It is truly said, “Prevention is better than cure”. Prevention of urinary tract infection is more important than its development and treatment. Following are some of the tips, which can be acquired to prevent urinary tract infection in men:

  • Drink a lot of fluids especially water. This can help flush the bacteria out of the urinary tract, and in mild infections can even help treat it completely.
  • Urinate as more as possible. Don’t hold your urine when you feel the urge to go.
  • Empty your bladder as much as possible when urinating.
  • Cleaning of the area is important, so that bacteria doesn’t get trapped and enter the urinary tract.

Other treatment strategies for UTI and erectile dysfunction include:

Lifestyle modification

  • Simple lifestyle changes, such as termination of smoking, weight loss and even modest but regular exercise, very often improve and can often resolve erectile dysfunction symptoms. Improvement in these domains serves to improve blood flow, tissue health and nerve function of penile tissues.
  • Diabetes also can be a risk factor for erectile dysfunction. Uncontrolled diabetes leads to poor long-term blood sugar control, and when blood sugar remains uncontrolled, this can cause nerve and blood vessel damage, negatively affecting the blood supply to the penis. Thus, blood glucose levels should be regularly monitored and managed accordingly.

Natural supplements

  • D-mannose is a naturally occurring sugar found in apple, blueberries and cranberries and is the most effective treatment for urinary tract infection. D-mannose sugar is effective because it attaches itself to the infection-causing bacteria and prevents them from sticking to the walls of the urinary tract, eliminating them while urinating.
  • One supplement popular among individuals with erectile dysfunction is Korean red ginseng, also called Panax. It’s thought that the ginsenoids found in ginseng are the active ingredient that improves sexual function. They are believed to have multiple potential health benefits, such as being antihypertensive, antidiabetic, antiatherosclerotic, and anti-inflammatory, as well as having positive effects on the central nervous system.
  • The body uses L-arginine to make nitric oxide, a gas that increases blood flow. Nitric oxide triggers the smooth muscle of the penis to relax, which then allows blood to flow into the penis, causing an erection.
  • Other natural supplements for the treatment of erectile dysfunction and raise overall energy and vitality in men include:
    • Yohimbine: It is believed to activate the penile nerves to release more NO, widen the blood vessels to increase blood flow in the penis, stimulate the pelvic nerve and boost adrenaline supply, increase sexual desire and prolong erections.
    • Fenugreek: Fenugreek has been known to boost testosterone levels to cure erectile dysfunction. Fenugreek-based supplement –CHEMFORCE is a natural dietary supplement for overall energy and vitality in men. Fenugreek extract, the major ingredient in Chemforce, has been known to boost testosterone levels to cure erectile dysfunction. It is a clinically proven and patented herbal supplement which helps to maintain overall health of men including healthy sexual function, healthy muscle development, maintenance of overall energy, etc.
    • Ginkgo: Ginkgo biloba may increase blood flow to the penis, thus, causing improvement in erectile dysfunction.
    • Mondia whitei: It is believed to increase libido and manage low sperm count in men. Studies suggest that this natural supplement increases human sperm motility, testosterone levels and NO production, thus, increases sexual desire.

REFERENCES

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Fenugreek Extract: An Alternative Sports Supplement

Fenugreek (Trigonella foenum-graecum) is a plant and its seeds are commonly used as a spice in Asia and many Indian cuisine. It’s not surprising to say that about 80% of the Fenugreek in the market comes from India known as the home of Ayurveda. The fenugreek extract appears to significantly improve muscle strength and weight lifting power output. Recently, fenugreek seed extract has made its way to bodybuilding supplement stores, as recent studies have shown that the seeds of the plant were able to increase testosterone levels, strength output, and even growth in hormone level.

Men dramatically improved their performance and athletic abilities with Fenugreek extract’s help in building stronger muscles. Some of the benefits of the seed extract are explained. 

2Protein content in Fenugreek

Fenugreek is extremely rich in proteins; eleven grams of the extract contain about three grams of protein. This may not sound like a lot, but proteins found in fenugreek are of extremely high quality and more importantly, they are natural and safe due to which bodybuilders avoid exposing themselves to synthetic ones, which are not natural and may cause damage.

Iron content

Iron increases blood’s abilities to transport more oxygen to muscle cells, which makes it really important for building strong muscles. Having low iron levels does not allow muscles to stretch and increase in size.

Energy levels

Fenugreek extract is associated with an increase in resistance levels and the energy levels available in the body. Thus we may say that consuming fenugreek is going to make bodybuilders train more, and do more in less time!

Lowering inflammation levels

By lowering the inflammation levels in the body, energy levels increases. High inflammations are going to increase the body’s risk to diseases, lower resistance to infections, and on the long run, make the body look older and unhealthy. Fenugreek is very rich in anti-inflammatory compounds and especially antioxidants, which are the ones responsible for lowering inflammation levels and are crucial for preserving overall health by protecting healthy cells from damage.

Zinc content

Although zinc may not “appear” as very important for bodybuilding, it is. It’s responsible for keeping energy levels healthy, and without zinc, body feels fatigue and exhaustion very quickly. Fenugreek is very rich in zinc and provides the body with healthy amounts that is not only very beneficial for keeping energy levels up, but is also very important for maintaining the immune system healthy and functioning optimally.

Getting rid of toxins and germs

A lot of bodybuilders are training extensively and consuming very rich food without ever achieving “amazing” results! This may be because of excessive parasites and germs in their intestines with which they share their food, energy, and even more. They release toxins in the blood stream of the bodybuilders. Fenugreek seeds and extract are very rich in anti-inflammatory, anti-septic molecules and more importantly, fibers, which are responsible for getting rid of toxins and parasites.

3Chemforce is an innovative product rich in protodioscin, which plays significant role in maintaining and improving testosterone levels, which further contribute in muscle mass building and safe sports supplement. It’s a unique blend of highly powerful ingredients, Furosap® which is a patent protected and clinically evaluated fenugreek seed extract and Alpha Yohimbine which is a known aphrodisiac. Furosap® has been proven safe and effective for maintaining overall energy and vitality in men.

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References:

http://www.formulaoz.com/shop/fenugreek-extract/

http://www.livestrong.com/article/206838-what-is-the-composition-of-fenugreek/

https://examine.com/supplements/fenugreek/

http://nutritionfacts.org/2013/04/23/increasing-muscle-strength-with-fenugreek/

http://www.fasebj.org/content/30/1_Supplement/1156.7

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ANDROPAUSE IN MIDDLE AGED MEN & BENEFITS OF FENUGREEK SEEDS EXTRACT

Introduction:

Testosterone (T) is a powerful male sex hormone produced by the testicles and is responsible for the proper development of male sexual characteristics. It controls sex drive, regulates sperm production, promotes muscle mass, increases energy and also influences human behavior (such as aggression and competitiveness). Levels of testosterone are at highest during adolescence and early adulthood. The first physical signs of testosterone or androgens in the body are apparent during puberty characterized by change in voice; broadening of shoulders and masculinization of facial structure. But as men get older, their testosterone levels decline about 1% per year after age of 30. The changes in testosterone with age in males are given below in the table:

Age Testosterone Level (ng/dL)
0-5 months 75-400
6 months-9 yrs. <7-20
10-11 yrs. <7-130
12-13 yrs. <7-800
14 yrs. <7-1,200
15-16 yrs. 100-1,200
17-18 yrs. 300-1,200
19+ yrs. 240-950
Avg. Adult Male 270-1,070
30+ yrs. -1% per year

In men, serum concentrations of testosterone get decreased to a greater extent with increase in age. This decrease in serum testosterone levels in men is referred as “andropause” or “late-onset hypogonadism (LOH)”. Several cross-sectional and longitudinal studies showed a decline in serum testosterone concentration, an increase in sex hormone-binding globulin concentration (SHBG) and a decrease in free testosterone levels with advancing age. Approximately 2.4 million men, aged 40 to 49 years, have low testosterone levels, with a new diagnosis of about 481,000 androgen deficiency cases a year.

Mechanism of decline in testosterone level during aging:

  • Male hypogonadism is a clinical syndrome caused by lack of androgens and may reflect abnormalities of the hypothalamus, pituitary, testes or target tissues. Testosterone levels found to be reduced in aged men. 20% of men aged over 60 years have total testosterone levels below the normal range and the figure rises to 50% in those aged over 80 years. Levels of gonadotropin rise during aging and testicular secretory responses to human chorionic gonadotrophin (hCG) are reduced. This shows that reduced testosterone level may be caused primarily by testicular failure.
  • There is also elevation in luteinizing hormone (LH) and the follicle stimulating hormone (FSH) levels (hypergonadotropic hypogonadism). Therefore, it seems like that there are changes in endogenous production of GnRH (gonadotrophin releasing hormone), which cause the changes in LH secretion and play a role in the age related decline in testosterone.
  • With increase in age, there is also a reduction in androgen receptor concentration in some target tissues and this may contribute to hypogonadism or LOH. Thus the decrease in testosterone levels with aging seems to reflect changes at all levels of the hypothalamic-pituitary-testicular axis

Consequences of low testosterone level during aging in men:

Testosterone is sometimes thought as “fountain of youth” hormone. Decreased testosterones levels lead to changes in sexual function and mood changes including

  • Reduced sexual desire or low libido
  • Fewer spontaneous erections
  • Erectile dysfunction or impotence
  • Osteoporosis
  • Changes in sleep patterns or depression
  • Emotional changes, such as low self-confidence or lack of motivation and energy
  • Physical changes, like increased body fat, reduced muscle bulk and strength, and decreased bone densitynew-1

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Fenugreek extract and its effect on testosterone boosting:

Medically, testosterone deficiency may be treated by using testosterone supplementation i.e. testosterone replacement therapy (TRT), which can boost testosterone levels back to normal. Testosterone deficiency can be treated by, intramuscular injections (given anywhere from two to 10 weeks apart), testosterone gel applied to the skin or inside the nose, mucoadhesive material applied above the teeth twice a day, long-acting subcutaneous pellet, testosterone stick (apply like underarm deodorant).  But this therapy has certain risks (such as blood clots and stroke) and side effects (such as sleep apnea, acne, and breast enlargement). Losing excess weight and being physically active can also raise a man’s testosterone level.

In traditional medicine systems like Ayurveda and Homeopathy, herbs and spices have been used since the beginning of time. Fenugreek (Botanical name: Trigonella foenum-graecum) is a plant, cultivated annually in Arabic regions and India, for use in food. The seeds are used as a spice in Indian cooking. Fenugreek seeds contain 45% dietary fiber, vitamins, plant sugars and minerals. Seeds and leaves of fenugreek provide various bioactive components such as steroidal saponins including diosgenin, yamogenin, gitogenin, tigogenin and neotigogens, other bioactive components including choline and trimethylamine, retinol, vitamin D, riboflavin, pyridoxine and essential oils.

Studies on Testosterone Boosting effect of Fenugreek:

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Maintenance of healthy testosterone levels:   

A clinical study conducted by Steels and co workers on 60 healthy males, aged between 25 – 52 years. The duration of the study was six weeks and 600mg extract of fenugreek seeds was consumed orally, by all the subjects. Serum testosterone and prolactin levels were estimated at the end of the study. The major outcome of the study was that levels of testosterone and prolactin were maintained within the normal physiological limits. Increased muscle strength and improved libido was also observed without any change in mood or sleep patterns. So it was concluded from the study that fenugreek extract helps maintain natural healthy testosterone levels.

2. Improvement in lean muscle mass and body composition:

Fenugreek is considered to possess aromatase and reductase inhibitor activities, the enzymes responsible for breakdown of testosterone in body. To determine this activity, a clinical study was conducted by Wilborn and co workers; in three groups of healthy trained men for 2, 4 and 8 weeks and 500mg of fenugreek extract per day was administered to all subjects. Testosterone levels, body fat , muscle gain and strength was evaluated at the end of study. Increase in testosterone levels was observed at the end of the study. A reduction in body fat was also observed that is directly linked to improved androgenic activity. Therefore it was concluded that fenugreek extract improves the testosterone levels by partially blocking the enzymes responsible for breakdown of testosterone.

3. Fenugreek acts by inhibiting enzymes that breakdown testosterone:

Fenugreek is considered to possess aromatase and reductase inhibitor activities, the enzymes responsible for breakdown of testosterone in body. To determine this activity, a clinical study was conducted by Wilborn and co workers; in three groups of healthy trained men for 2, 4 and 8 weeks and 500mg of fenugreek extract per day was administered to all subjects. Testosterone levels, body fat , muscle gain and strength was evaluated at the end of study. Increase in testosterone levels was observed at the end of the study. A reduction in body fat was also observed that is directly linked to improved androgenic activity. Therefore it was concluded that fenugreek extract improves the testosterone levels by partially blocking the enzymes responsible for breakdown of testosterone.

CHEMFORCE is a precise & powerful blend of cutting edge natural ingredients designed to support healthy testosterone activity levels. It has been devised exclusively for men over the age of 18, featuring one of the highest ultra powerful protodioscin contents available.

CHEMFORCE is a natural and promising dietary supplement comprising Furosap® containing Protodioscin as the major fraction. It is reported to improve sperm count, sperm morphology and has a protective effect on male reproductive system. Furosap is a patented and clinically evaluated product with proven efficacy and safety,chemforce-boxReferences:

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FENUGREEK & ITS ROLE IN ERECTILE DYSFUNCTION

ERECTILE DYSFUNCTION (ED)

Introduction

  • The inability to maintain or develop an erection of the penis during sexual activity in humans is termed as erectile dysfunction.
  • The development of erectile dysfunction in men increases with age. It increases from 5% to 15% as the age increases from 40 to 70 years. It is also estimated that the prevalence of erectile dysfunction will double in the next 25 years.

 

Causes

  • Mechanism of cause: An erection occurs when blood 2fills two chambers known as the corpora cavernosa. This causes the penis to expand and stiffen, much like a balloon as it is filled with air. The process is triggered by the action of free radical e. nitric oxide, impulses from the brain and genital nerves. Anything that blocks these actions or restricts blood flow to the penis can result in ED.
  • Other causes of erectile dysfunction are:
  • Cardiovascular disease
  • Diabetes: Men with diabetes are more likely to have erectile dysfunction. They experience the problem as much as 10 to 15 years earlier than men without diabetes.
  • Lifestyle: Smoking, excessive drinking, and drug abuse may damage the blood vessels and reduce blood flow to the penis.
  • Surgery: Treatments such as surgery for prostate cancer, bladder cancer or BPH can damage nerves and blood vessels near the penis. This causes the lowering of blood flow and interferes with normal erection.
  • Hormonal insufficiency
  • Side effects from drugs such as including certain blood pressure drugs, antidepressants, and tranquilizers.
  • Psychological causes: performance anxiety, stress or mental disorders
  • Bicycling: according to the reported studies, the shape of the bicycle seats put pressure on the perineum. This area contains arteries and nerves which are damaged due to cycling for long time. This causes ED.

 

ROLE OF OXIDATIVE STRESS IN ERECTILE DYSFUNCTION

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  • Oxidative stress: It is the imbalance between the production of free radicals and their detoxification by antioxidants inside human body. Superoxide (O2) is the most important among other free radicals such as hydrogen peroxide (H2O2), hypochlorous acid (HOCL) and peroxynitrite (OONO) which are involved in pathophysiological mechanism of many diseases.
  • Mechanism: Normal erectile function is dependent on the action of free radical e. nitric oxide. It acts as a neurotransmitter in the process. Under oxidative stress, the free radicals are started to produce in excess amount. The reaction of nitric oxide with other free radicals such as superoxide, leads to the disturbance in normal erection mechanism. During this imbalance, nitric oxide starts to deplete in the human body and the target action of nitric oxide i.e. penile smooth muscle relaxation, starts to fade away. This causes the ineffective relaxation in cavernosal tissue and lack of penile blood flow which results in erectile dysfunction.

 

ROLE OF ANTIOXIDANTS IN TREATING ERECTILE DYSFUNCTION

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  • Antioxidants: Antioxidants are those molecules which react with free radicals to stabilize them and inhibit their unwanted reaction at other sites in the human body. They are one of the treatment options for oxidative stress-generated erectile dysfunction.
  • When free radicals cause erectile dysfunction through reacting with nitric oxide then, antioxidants work by one of the following two mechanisms:
  • Antioxidants either interfere in the production cycle of free radicals i.e. they inhibit the production of free radicals.
  • Or, they react with free radicals to stabilize them and block their reaction with nitric oxide.
  • In any case, antioxidants inhibit the reaction of free radicals with nitric oxide due to which oxidative stress is released from the cells. This causes the smooth muscle relaxation and penile blood flow which results in cavernosal tissue relaxation. Thus, erectile dysfunction originated from oxidative stress is prevented. This has also been proved by animal studies that antioxidant therapy is a good pharmacological approach to prevent erectile dysfunction.

 

FENUGREEK TO TREAT ERECTILE DYSFUNCTION

Introduction to fenugreek: Fenugreek is an herb, which is used traditionally in many countries as a therapy against some diseases. The seeds & leaves of fenugreek are responsible for the therapeutic properties of it. Seeds and leaves provide various bioactive components such as steroidal saponins including diosgenin, yamogenin, gitogenin, tigogenin and neotigogens, other bioactive components including choline and trimethylamine, retinol, vitamin D, riboflavin, pyridoxine and essential oils which contribute to the antioxidant property of fenugreek.

DUAL ACTIVITY OF FENUGREEK IN ERECTILE DYSFUNCTION

 

Fenugreek helps in the treatment of erectile dysfunction by any of the following two mechanisms given below:

Fenugreek as antioxidant: In-vitro studies prove that fenugreek has great antioxidant property. The phenolic and flavanoid compounds present in fenugreek seeds help to fight against oxidative stress. Thus, fenugreek is able to block the chain of the formation of free radicals inside body. Due to the chain inhibition, oxidative stress is also inhibited. Thus, free radicals do not react with nitric oxide in the cavernosal smooth muscles and make its availability for erection mechanism.

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There are many published studies, which prove that antioxidants inhibit the reaction of excessive free radicals with other molecules in the body to reduce oxidative stress so that erectile dysfunction can be treated. Some of those studies are given below.

  • Kaviarasan S et al. (2007) conducted an antioxidant analysis on fenugreek seeds. Their results showed that fenugreek was able to scavenge hydroxyl radicals and also inhibited hydrogen peroxide-induced lipid peroxidation. This proves that fenugreek inhibit the free radical chain reaction. Thus, according to Azadzoi et al. antioxidant therapy by fenugreek will help to inhibit the reaction of free radicals with nitric oxide. This will further help to carry out normal erection mechanism by nitric oxide.
  • An in-vitro study conducted by Naidu MM et al. (2011) showed that fenugreek seeds are a valuable source of saponins, protein, dietary fiber and phenolic acids. These bioactive components are a natural source of antioxidants. Fenugreek was able to inhibit the activity of free radicals under in-vitro This analysis shows that fenugreek will be helpful in relieving body from oxidative stress. This in turn, will help to enhance the activity of nitric oxide.
  • Achike FI & Kwa CI published a study showing the role of nitric oxide in many physiological pathways. They showed that polyphenols have a major role to boost the effect of nitric oxide. Fenugreek also contains polyphenols as one of its bioactive components which will be beneficial to boost nitric oxide activity. Boosting of nitric oxide activity will help in normal erection mechanism.

 

Fenugreek as testosterone booster: The erectile dysfunction also originate if the body does not have sufficient amount of testosterones. It has been proved by many clinical studies that fenugreek has the testosterone boosting activity. When the testosterones are boosted-up then, the body also shows improvements from erectile dysfunction.

  • It is suggested that herbs for treating erectile dysfunction are better than testosterone replacement therapy. Natural treatment for erectile dysfunction does not give rise to side effects such as heart attacks or becoming dependent on therapy. Fenugreek is reported to restore the normal testosterone levels in the body by acting as an antioxidant.
  • Fenugreek has the ability to treat erectile dysfunction originated from hormonal deficiencies. It helps to promote natural testosterone levels and improve libido. It contains phytochemicals such as saponins & sapogenins which are responsible for raising testosterone levels in men.
  • It has been proved by a clinical study that standardized extract of fenugreek had positive effect on physiological aspects of libido of 60 male subjects with 25-52 years of age. Fenugreek extract helped to maintain normal testosterone levels in men. Fenugreek was able to increase muscle strength, energy and well‐being in males. Due to this, the erectile dysfunction originated from testosterone deficiency can be prevented.
  • In a randomized, double blinded and placebo controlled clinical study on 16 male subjects, it was observed that fenugreek seed extract was able to increase free testosterone and total testosterone levels in the subjects. Fenugreek was also found to be safe and well-tolerated. This clinical study shows that fenugreek supplementation has potential androgenic benefits in males.
  • CHEMFORCE is a natural and promising dietary supplement comprising Furosap® containing Protodioscin as the major fraction. It is reported to improve sperm count, sperm morphology and has a protective effect on male reproductive system. Protodioscin is known to increases levels of the hormones; testosterone, dihydrotestosterone and dehydroepiandrosterone. It boosts testosterone levels via stimulating pituitary gland. CHEMFORCE consists of a patented and clinically evaluated ingredient establishing its efficacy and safety for overall energy and vitality in men.

 

According to these reported studies, choosing fenugreek as a natural therapy to treat erectile dysfunction has proved to be safe and effective in men.

 

References

 

 

 

 

 

 

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Signs of Low Testosterone Level

Testosterone is a hormone produced by the human body. Generated mainly by the testicles of men, it stimulates sperm production, a man’s sex drive and also helps build muscle and bone mass. Testosterone production typically decreases as men age however men can experience a range of symptoms if it decreases more than it should. Below is a list of common symptoms of Low Testosterone Level

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CAUSES OF LOW TESTOSTERONE

Testosterone is often termed as the MALE HORMONE. Testosterone is a steroid hormone from androgen group. It is the most potent of naturally occurring androgens. Testosterone plays a pivotal role in development of male reproductive tissues such as testis and prostrate and is also responsible for the development of the male sex characteristics such as deep voice, growth of body hair, increased muscle and bone mass. Testosterone is often termed as the MALE HORMONE. Testosterone is a steroid hormone from androgen group. 

The medical condition when the testicles don’t produce enough of the male sex hormone testosterone is known as HYPOGONADISM. There are two types of Hypogonadism:

Primary: Also known as the primary testicular failure, it originates from a problem in the testicles.

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